personally, i tried to get every single quartz/gem along the way, with sanguine signet and snowboots. then i switched to winterheart at magma level, using mageflare runes every couple of digs, and if i ran out of stamina, i switched to alchemist's pouch and used my flask. you should probably get the full flask before you attempt nix, though.
and use the reeler hat. i believe it's lucky.