currently playing on hard and the inability to run from fights genuinely ruins the game. literally completely screwed over if i'm forced to encounter the neighborhood watch and get stuck in a viscous cycle with the hungry plant where it just soul drains over and over making me waste all of my heal items till i inevitably die and have to start from last save.
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I would not suggest playing on hard mode unless you have played on normal first and have decided that you would enjoy a significantly more difficult experience. The lack of an ability to run is intentional, and the game is balanced around this, however the game is balanced for normal mode, as it is the primary intended experience.