I'm using the itch app on PC, Windows 10.
Maybe my app is just having one of its occasional hiccups again, wouldn't be the first time.
Viewing post in Public Build V0.6.1: The No-Wank-Master comments
I tested both uploaded windows builds on a WIN10 machine, and could run them without problem. These are the exact same zip-files the itch.io installer uses to patch the game, so it is probably the installer messing up somehow. I recommend backing up your savefiles manually, and reinstalling the game. Hopefully that fixes your issues.