I'm new to the game, downloaded it today, so I don't know if these issues are news to you or not.
First, the skeleton key breaks after the first door. I found out later that I keep my existing inventory when I start a new game; and I used that as a work around.
Second, after successfully seducing an enemy, and winning the sex game, they become hostile gain when I walk in front of them.
Third, even loading/continuing is treated as a new game. I even got to the town outside, saved and exited. When I came back, I'm back to the very beginning.
That said, I'm still interested in the game.