Nice game so far!
I notice the enemies struggle to follow you. Going up and down the level is an easy way to kite the green guys. The imps and the final boss suffer from this issue as well.
The weapon having 20 shots feels weird? It takes you by surprise when you need to reload. In my case doubly so, with two +60% damage early on I rarely needed to reload in the first levels.
Unprompted suggestion: Lust Shots: every 5 shot is a Lust shot, which stuns the enemy for a short duration. If you defeat an enemy with only Lust Shots, you get a lewd animation of them. Artifacts could interact with this by making Lust Shots more frequent, removing their stun in favor of more damage, making them regen hearts...