Hey, thank you for the very detailed feedback! A bunch of this will be changing in the next update (it's a big one) that eases most of your issues. Some examples below:
Internal request should be repeatable and procedural, so it shouldn't be the same and will give variable rewards each time.
Statwise, I think we will be looking to redefine the stats and have them be a little more detailed so as to have a few more levers to pull and reasons to make some species over others, for different purposes.
Quality doesn't yet affect anything but it is something we're working on.
You will ideally be able to make your own species by taking a sequenced gene and adding or replacing parts from other sequenced genes, and then using that as the base for a serum.
We'll also be looking to rework sex/gender in the game, though it may increase the maturity rating of the game. It will likely be more explicit in what exactly is changing, because as it stands the nebulous masc/fem labels are confusing more than they enlighten. The original intention was male = all male parts & mutations, masc was female parts but can have male mutations, intersex they can have any of either, fem is male parts but female mutations, and female is all female parts & mutations. A female serum used on a male will pick between feminine/female/intersex, and the patient will eventually end up there, but can gain the related mutations before that full change actually happens.
It'll be clearer in the next update where that will be spelled out in plain anatomical detail, but I'm still to determine if we go further and have mutations for such parts. I understand many gamers enjoy the lewd aspect, but many also prefer a purely scientific approach. I'm in two minds about it, and it probably warrants a checkbox.
There is a LOT that's changing and being added to the next version, I think you'll like it!