I generally put multi hit attacks to have a lower hit chance, about 75% instead of the default 90-95%. I'll take another look at Frail Fever but it shouldn't be possible to get it with the "Bite" because I think Werewolves use the same skill and they don't transfer that disease.
Lycanthropy works like the Berserk state in most RPGs, it pumps up your fighting stats but causes you to just auto-attack every turn.
Well she does wear them when she goes out to "rent" a boyfriend for the night if you turn down her offer of sex as a reward for the dress, so I assume they would have had their argument then! (The argument doesn't actually happen in game though).