I guess it depends on if you want to make a Gameboy game, or just a game that looks similar. Everyone that uses GB Studio will be limited by file size, number of sprites, type of audio, not to mention resolution of tiles, sprites, screen, etc. Plus everything made with GB Studio can actually be played on a real Game Boy.
Up to you, unless AuriosiYT has something to say about it.
Unfortunately, I did not think about people wanting to use other engines, so I said nothing about it. Also, since the jam is almost over and I will probably start a second jam that is more organized and refined, as long as it is developed with software that can produce GB games.
