Hey! What I would do is take a game genre and remove the most crucial information, for example an RPG but you don't have quest pointers, so you have to ask other people, an FPS game where you don't see your ammo, a survival shooter with invisible enemies (you have to use sounds instead), or remove all of the UI, you can replace a crucial mechanic with a new mechanic forcing your players to experience something unique. Hope that helps :)

Even if you don't have any ideas just make something you want to make, and then you might get an idea on a twist, experimentation really helps!