Top rated games with Mouse support tagged 2D

Explore games with Mouse support tagged 2D on itch.io. Uses two-dimensional "sprites", 2D images created and used on a flat plane, as opposed to the three-dimensional models o · Upload your games with Mouse support to itch.io to have them show up here.

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Backpack Hero

$19.99

The inventory management roguelike! Collect rare items, organize your backpack, and vanquish your foes!

Thejaspel

Rated 4.8 out of 5 stars

(2,019 total ratings)

Role Playing

Play in browser

Therapy with Dr. Albert Krueger

dino999z

Rated 4.8 out of 5 stars

(2,098 total ratings)

Interactive Fiction

Vampire Survivors

Mow thousands of night creatures and survive until dawn!

poncle

Rated 4.8 out of 5 stars

(1,341 total ratings)

Action

Play in browser

last seen online

Look through someone else’s computer. Inspired by early “escape room” flash games.

qwook

Rated 4.9 out of 5 stars

(1,269 total ratings)

Puzzle

Play in browser

GIF

Exhibit of Sorrows

Have fun with seemingly friendly dolls and a not so friendly clown.

adayofjoy

Rated 4.8 out of 5 stars

(1,474 total ratings)

Simulation

Play in browser

OneShot

$10

A surreal puzzle adventure game with unique mechanics / capabilities.

futurecat

Rated 4.9 out of 5 stars

(1,031 total ratings)

Role Playing

GIF

her tears were my light

a love story between time and space

NomnomNami

Rated 4.8 out of 5 stars

(1,109 total ratings)

Visual Novel

Play in browser

one night, hot springs

a young transgender woman goes to the hot springs.

npckc

Rated 4.8 out of 5 stars

(1,197 total ratings)

Visual Novel

Cryptid Coffeehouse

the (moth)man, the myth, the legend: now in sexy dateable human form

nukes

Rated 4.9 out of 5 stars

(518 total ratings)

Visual Novel

Syrup and the Ultimate Sweet

a candy alchemist finds a candy golem in her basement workshop

NomnomNami

Rated 4.8 out of 5 stars

(1,191 total ratings)

Visual Novel

Play in browser

Lo-Fi Room

Build lo-fi beats in this hidden object / rhythm game

Bearmask

Rated 4.7 out of 5 stars

(1,429 total ratings)

Rhythm

Play in browser

good morning!

a morning routine simulator ｡･:*:･ﾟ★,｡･

cnnmon

Rated 4.6 out of 5 stars

(2,151 total ratings)

Simulation

Play in browser

Contract Demon

an angel summons a demon. they fall in love.

NomnomNami

Rated 4.7 out of 5 stars

(1,264 total ratings)

Visual Novel

Play in browser

GIF

HOW WE KNOW WE'RE ALIVE

A point-and-click mystery set in the bible belt of Sweden

Motvind Studios

Rated 4.8 out of 5 stars

(846 total ratings)

Adventure

Time is Solid Here

A horror puzzle game about helping people move on.

AlgebraFalcon

Rated 4.8 out of 5 stars

(648 total ratings)

Puzzle

Play in browser

Blackout

Point & click adventure set in a spooky house!

FRESH

Rated 4.8 out of 5 stars

(911 total ratings)

Adventure

Play in browser

P.E. Noire

Point and Click Softboiled Detective Story

Picogram

Rated 4.7 out of 5 stars

(1,073 total ratings)

Puzzle

Play in browser

Cafe in the Clouds

Two cooks turn dream eaters when troubled, sleepless townsfolk seek their unusual services.

Cafe Nemo

Rated 4.8 out of 5 stars

(759 total ratings)

Visual Novel

what body?

Clean your room!

bun_tired

Rated 4.8 out of 5 stars

(720 total ratings)

Play in browser

Someone Stole MY LUNCH!

A short comedy visual novel about your lunch and a thief... both of which are hot.

Studio Clump

Rated 4.8 out of 5 stars

(760 total ratings)

Visual Novel

GIF

Mr.TomatoS

In bundle

Welcome to my game, buddy!

OXTORD games

Rated 4.8 out of 5 stars

(626 total ratings)

Educational

GIF

hi no homo

realistic simulator of awkward people saying hi

angela he

Rated 4.6 out of 5 stars

(1,564 total ratings)

Simulation

Play in browser

GIF

Red Handed

A stealth game where you have to get caught

Bad Piggy

Rated 4.7 out of 5 stars

(1,064 total ratings)

Action

Play in browser

GIF

Monster Girl Maker

Character creator themed around cute and creepy monster girls!

Emmy- GhoulKiss

Rated 4.6 out of 5 stars

(1,308 total ratings)

Role Playing

Play in browser

(Don't) Open Your Eyes

A short, horror visual novel about a midnight visit from a strange being, who demands you open your eyes. Will you?

Via

Rated 4.6 out of 5 stars

(1,117 total ratings)

Visual Novel

Arcade Spirits

$20

A Romantic Comedy Narrative Game

Fiction Factory Games

Rated 4.7 out of 5 stars

(940 total ratings)

Visual Novel

Return of the Tentacle

Sequel to the Point&Click-Adventure "Day of the Tentacle"

catmic

Rated 4.9 out of 5 stars

(231 total ratings)

Adventure

BASES LOADED

baseball survivors

kindanice

Rated 4.7 out of 5 stars

(551 total ratings)

Action

Play in browser

Dark Nights

Nothing is what it first appears.

pinlin

Rated 4.7 out of 5 stars

(555 total ratings)

Visual Novel

Signs of the Sojourner

$19.99

An introspective deck-builder about friendship, travel, and collecting snacks.

Echodog Games

Rated 4.7 out of 5 stars

(501 total ratings)

Card Game

Among Us

An online and local party game of teamwork and betrayal for 4-15 players

Innersloth

Rated 4.5 out of 5 stars

(1,533 total ratings)

Pyre

$19.99

Pyre is a party-based RPG from the creators of Bastion and Transistor.

Supergiant Games

Rated 4.8 out of 5 stars

(341 total ratings)

Role Playing

TOMATO CLINIC

donate blood for vampires! a visual novel.

npckc

Rated 4.7 out of 5 stars

(573 total ratings)

Visual Novel

Dog Wash

Wash a Doggo!

Tony LindoRock

Rated 4.7 out of 5 stars

(419 total ratings)

Simulation

Play in browser

GIF

Handshakes

Achieve Connection Nirvana!

Pet Pumpkin

Rated 4.8 out of 5 stars

(384 total ratings)

Puzzle

Play in browser

Little Chef

A fun and cute 2D physics-based cooking game with a focus on experimentation and discovery.

Julien

Rated 4.7 out of 5 stars

(413 total ratings)

Simulation

Play in browser

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Top ratedGamesGamesToolsGame assetsComicsBooksPhysical gamesAlbums & soundtracksGame modsEverything elsewith Mouse support tagged 2D (9,718 results)

New itch.io is now on YouTube!

Top rated
Games Tools Game assets Comics Books Physical games Albums & soundtracks Game mods Everything else
with Mouse support tagged 2D (9,718 results)