Introducing Dose Response! You're an addict. You need to use doses to keep going, but as you do, your tolerance increases and you're driven to stronger stuff. Be careful not to overdose!
It has streamlined controls (you move around, use items and that's it), short gameplay (about 5 minutes per run) and it's easier to learn and play than the more traditional roguelikes (despite looking similar). I think it's a good introduction to the roguelike genre.
Dose Response is Free, Libre and Open Source software (source code linked from the game page below) available for Windows, Linux and OSX.
https://tryjumping.itch.io/dose-response
Trailer:
Screenshot: