I just had a necromancer lose 50 hp in a single turn in the 2nd Vault of Yendor. I thought I was safe for one more turn, was planning to quaff a healing potion next.
I could learn a lot more from this if I wasn't stuck unable to examine the dungeon after death. All I can take away from this as-is is "You should examine everything that can possibly hit you in the boss room", which I know I'm probably not going to do next time either, because I'm too lazy
Perhaps 'ghost mode' after you die would be nice, where you can just float around and examine stuff.