I suppose it might be the long way but I traditionally work in Unreal Engine and have been growing in experience with Metahuman. It occurred to me that I could set up any scene I'd like with the characters in the engine and set up a camera to capture photos from any angle. After taking the photos, I convert them into pixel art. I really enjoyed how the results turned out and figured I'd share. 

Check out my game Oscar at https://bluntdmc.itch.io/oscar