When a Twisted_Skeleton3D, Skeleton3D, and Twisted_ModifierTwoBoneIK3D (target and pole) nodes are all rotated, the solver gives different results as the rotation occurs. This is not desired, as when everything that affects the TwoBoneIK solve is rotated, it shouldn't change the result as all the data points (joints, target, etc) are all in the same position.
This is a known issue and I am looking into finding a fix. Ideally this issue will be fixed in version 2.2.0, but it may be bumped to version 2.3.0 depending on how much time I can dedicate to fixing it.
This issue is similar to the FABRIK one mentioned here: https://itch.io/t/1260217/fabrik-and-solver