It's generally 16 colors (or 15 + transparency, really) per tile, which means most sets use a single 16-color palette for a particular layer or bunch of sprites. It does cut your colors down a bit but it'd be awesome if it could be mapped that way. I'll have a peek with ProMotion and see if I can remap them... (need to buy one first though :-) )
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Quick question about the palettes associated.. Any chance they are / can be mapped into 16 colors? For systems like the Sega Genesis and GBA, most tiles are 16-colors only, so it'd be awesome if they'd fall into that..
ProMotion from Cosmigo hands down for me (www.cosmigo.com). Although I like the earlier versions better than the latest one. The older versions were pretty much a replacement for DeluxePaint