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Just keep Transcending. Maximise your Cell-growth via all Proteins, Tissues and not more than 7 Neurons.

If you only focus on Transcending, you'll reach 1Q Cells at around +2.000% Growth.

Then you're nowhere near the end. 682 has 32 Evolutions total, the last one is reached at 100T Cells. Transcention makes those numbers way easier to reach.

It's best to transcend when able. At some point, you'll reach the last evolution while waiting to reach the number of Evocytes neccessary for your next Transcention.

In the beginning, don't go higher than the 1,5k Cell generator and start raising Genes as soon as possible.

Once you have multiple Gene-generators and one or two auto-clickers (Tissue) get into Neurons, but never unlock more Neuron-generators than you have Gene-Generators.

Those allow you the highest Cell-production, which should easily avail you 15 Billion Cells to create the automated Xenocyte killer. Once you have that, go nuts with Cell-generators until you have enough to Transcend.

No, only the Cell upgrades increase the number and size of Xenocytes spawned. until you've got a number of Transcentions, it's easiest to let the weak Xenocytes accumulate to 33 and then kill one only, once you've gotten the auto-killer.

You won't need to keep your Neurons in sight if you take only as many upgrades to them as you have Genes. It your Genes grow faster than your Neurons, the Tissues auto-clickers iron out any loss in Cells the Neurons generate.

Can you transcend to reset your stats? That seems like the only possible escape here.

I usually just let the green ones block the arrival of any more advanced ones. If you transcended once, you won't even need a single Neuron before you've reached the auto-killer.