The expensive items were honestly a late decision to add something of a end game (along with these I also added the permanently unlocking the 2 doors) and I tried to make speedrunning an option after you "beat" the game, thus the run time at the run over screen. I made the decision to not continue development after the jam was over, but if I ever do come back to it, I agree it needs rebalancing. Thanks!
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On the run over screen (The "You win!" or "You lose!" screen), you can play again or return to the menu and then the shop. You can consider each "run" as a level basically. It's just what I call it. Each run consists of 5 plagues and you need to get 5 slabs to win the run. Also, interesting input about the escape button thanks!