I managed to pretty consistently trigger it, if you try to drag an item around too out of position before the dragging/snap sound effect triggers it crashes.
The problem of course is that the more that you crash the faster you want to play, so multiple times I tried to quickly drag something to my inventory and it would crash the game because I did it too quickly. This pretty much made it impossible to grind out high difficulty runs since you desperately need to reroll into the stronger strategies (cough Farmer's Warning cough) to have any chance of winning.
I eventually managed to get all the way to Impossible difficulty, but when I went to beat the second boss It never actually started the fight, forcing me to restart.