I've learned about a way that uses a small shell Mac app and the resources of an AGS game can be put into the app. This greatly reduces the size of the app so all of the Wine-related files are not necessary. I've already helped port a couple of apps to the Mac. I have an extensive blog post that I'm writing which will detail more of this process which I'll release some day.
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Awesome, hint! The Windows version comes with a winsetup.exe program. Does anyone know if there is a similar Mac app? If not, I'd consider writing a little app which can be used to help configure the settings for Mac versions of games created with the Adventure Game Studio.
I see that this game was created using the Adventure Game Studio, so there is an easier (and MUCH smaller) way to port the game over to the Mac that will run on macOS Mojave and Catalina. I'm testing out a port of the game. I'm not using Wine, so the app has been reduced from a hefty 590 MB to a svelte 57MB.
Since this game was designed using AGS, making a Mac port is relatively simple. I already got a quick proof of concept running and would be glad to help out with an official Mac version of this game.