The ISOs that Dreambox expects are just regular old ISO-9660 .iso files, exactly the same as you'd burn to a CD-R. The only requirement is that the ISO file should have the "main.wasm" file located in the root directory.
There's a few utilities you can use to make ISO files. If you are ok with installing cargo, you can use that to install the "mkisofs-rs" utility and use that to bundle your ISO files, which is what the Rust toolchain for Dreambox uses under the hood.