This is really fun! I love the concept, and it's executed very well. That last level was tricky until I figured out the trick to it haha
Aiwi
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Thank you for giving it another try! The rules for efficacy calculation are pretty much to use big particles (blue,pink,white), not repeat colour or letter ("zyz" bad, "boz" good), and have good synergy. The synergy value is determined by what particles are combined as it picks the value by sampling from a 3Dish noise texture using the particle makeup as coordinates for sampling (this one requires trial and error to figure out and even I don't know what particles combine to form the best synergy). 3.5k is a good score, especially considering how hard it is to grow particles up. I'll try and make a write-up to explain it a little better as someone suggested but I am happy you hear you had fun with it!
Thanks for playing! I haven't had too many issues but I also haven't been rigorously testing. I use Firefox and it's worked fine, I haven't heard any complaints from Safari or Chromium-based users. I did have to turn on SharedArrayBuffer support on the game page so that it would load otherwise I just got a message asking for it to be turned on. But it's been smooth sailing, otherwise!