I'm not sure it's Windows 10, unless it's a conflict with NVidia cards on Win 10. I've been using a Windows 10 laptop for the bulk of the development lately, but with an onboard graphics card. I desperately need a better PC, so I'll look into getting one with an NVidia card as soon as I can afford it.
I'll get it working, if I have to port the entire thing to Unreal Engine! Just without being able to replicate the bug, I can't start doing any tests to track it down.