I tried your suggestions, but unfortunately, they didn't work. Here is a save that has the bug. I hope this isn't too much of a headache, thank you for looking into it.
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Alright, so the good news is that I can't replicate any of these errors when opening your save file on my computer. The bad news... is that I can't replicate any of these errors when opening your save file on my computer. These errors happen every time you use check appearance or open and close the options, right? Just to make sure I didn't just get (un)lucky when testing your file.
Assuming you do get errors every time while I never get them, it means there is almost certainly something going on with your computer specifically, rather than the game itself. The most likely thing for that is again a permissions issue, which reminded me of another user who had the same error as you... 4 years ago lol. (Specifically the error: EPERM one after closing the options menu.)
The main thing I noticed that could be causing issues is that the game folder used to not have spaces in it, but for some reason, I stopped using underscores and started using spaces. Sometimes computers don't like spaces when reading files, for some reason. So maybe try renaming your games folder from "CiC 0.46.9 Windows" to "CiC_0.46.9_Windows". Or just erase the spaces. It doesn't really matter what it's named as long as there's no spaces. And also continue trying to run it as administrator when launching with any of the suggestions I'm listing.
Otherwise, the things that fixed the other user with the issue are mostly things I've already suggested. Running as administrator seemed to do it, but their reply was kind of vague, and I also suggested changing their account to be an administrator at the same time, so I'm not entirely sure which suggestion fixed their issue. If changing the name of the game's folder doesn't work, you can try checking if your profile is an administrator or not. Here is the link for that. https://www.windowscentral.com/how-change-user-account-type-windows-10
I also suggested they move the game on their computer as I suggested you try, but to be more specific I suggested they put it directly onto their C drive, so the filepath would be C:\CiC_0.46.9_Windows (With the spaces removed). You can get read/write errors from the filepath being too long, so that's also a possibility.
If all of that doesn't work, I'm not 100% sure what else to try. Have you run other RPG Maker games without encountering these issues? If you have that could maybe point to me being wrong about it being a permissions thing, idk. Hopefully the above works.