Win 11 works well with Ren'py (I use it myself) so it wouldn't be that. The only thing I can think of is that:
1. Your drivers may be messed up. Try a full power down to reset them.
2. You may have a corrupted download. Try downloading the game again (ideally using an ethernet cable).
Viewing post in Corrupted Kingdoms (NSFW 18+) comments
So just to be clear, all Ren'py games fail to run on your machine but games made on other engines - like Unity - work fine?
If so, there's a few things that you could try, in order from most likely to least likely:
1. Press and hold the SHIFT key when you launch the program - that will bring up a special menu. Select a different renderer and try again.
2. Same thing as #1 but disable controller support (game might be detecting a non-existent controller and crashing when it tries to communicate with it).
3. If you have the game installed to a OneDrive folder (ie. a folder that OneDrive tries to backup to the cloud) then move it somewhere OneDrive can't find it.
4. Related to #3 - try placing the game folder in the "Program Files (x86)" folder in windows (C:) drive.
5. Right-click on the game .exe and change compatibility mode to Windows 8 ("properties" > "compatibility" tab).
Hopefully one of the above solutions works for you! :)