It happens after playing for a long time, but since it’s a long game, that just means about 2/3 of the way through the game (the third deck).
I especially mentioned safari since safari also crashes on Reddit for me after scrolling too far, and it’s the whole page crashing, not just the game; however, no other itch game has this effect. If no one else reports this, I would just ignore it, but it might hint at some memory leak issue.