oh dear. that's entirely new - ive never seen this crash happen before.
im personally not sure how to fix it, but i might be able to offer a way to sidestep the problem, potentially:
easyRPG is an open-source tool for "emulating" RPG Maker 2003 games (the engine this is made in!). it can occasionally help with issues like this. once you've downloaded it, simply put the program into the same folder as "RPG_RT.exe" and, instead of running "RPG_RT.exe", instead, run easyRPG and select the game from the list that should be displayed (if it doesn't start running on its own).
i have to say though that this instability, and the apparent save-file corruption worry me. i know that RPG Maker 2003 games will occasionally interact badly with certain peripheral applications related to controllers. if you have any controllers plugged in, or any software intended to facilitate controller-use, that might be a problem. but unfortunately, im not sure what could be happening here.
ill be doing some research, and will let you know if i find a more straight-forward fix. until then, please let me know if easyRPG worked. thank you, and i apologise for the problems :,)