You do not know much anime, do you? Plotwise there are not really any bars for that style. Especially if you want to break from what is accepted or rather unaccepted to depict with real humans. If you want reference material, maybe look at some Elfenlied. I could not imagine getting that done in pseudo realistic style. Or rather, I would not want to.
In the end it depends on her audience and how the rest of the setting looks. The style on the left is what I might expect from a high value comic book graphic novel, or at least it's cover image.
I assume this is not the typical visual novel audience, so maybe chosing anime style because it is a vn, is not sound reasoning. It might be the better choice for other reaons.