Hmm that's weird, the `cache.ini` file should be located at the same place even when changing versions (`C:\Users\[USERNAME]\AppData\Roaming\Pixelorama\` on Windows, `~/.local/share/Pixelorama/logs` on Linux and `/Users/[USERNAME]/Library/Application Support/Pixelorama/logs` on macOS).
Which platform are you using Pixelorama on, and if you are using Windows, are you using the stand-alone zip version or the installer?
As for UI, in the current versions it's not being saved automatically. To save changes made in the UI layout, you need to go to Window > Layouts > Manage Layouts > Add. If you want to change it later, you need to go to Manage Layouts again and select Edit. In version 1.0 this will change and layouts will be saved automatically whenever you make a change.