Is the comment regarding the incompatiblity of the cartridge with EF or Ultimate still valid? Or is there (now) a way to run the cartridge (with saving) on physical hardware?
EF is incompatible with Sam's Journey still, however 1541Ultimate has updated its firmware to support GMod2 (the cartridge that Sam runs on).
Of course, there is also the possibility of obtaining Sam's Journey on a physical cartridge from protovision.games directly.