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I know because I have done this myself by accident  and have therefore soft locked  my game . It would be great if the dev's removed choices that can easily be missed because I don't want  to start all over again dev's please add auto saving on important choices so you can't screw up like I did 

The loading screen has a quick save section where you can find automatically generated saves for the last three days of the game.

This is enough to undo some of your actions.