After unlocking the loot and loot stacking options and getting a few stacked powerups (a challenge) you turn into an unkillable godship that can only die from carelessly running into a stray fireball, it seems. Certainly an interesting concept but if it's gonna be an infinite game it should get progressively harder throughout the run until you die. There also doesn't seem to be any incentive to actually use the options that make it harder unless you just want more of a challenge, I suppose.