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Is it possible, after selecting a card (card action pack 1), to modify its variables (using idenpendent card variables)? Something to simulate Yu-Gi-Oh equip cards?
Yes, that is what one of the Card Actions in Independent Card Variables is set to do. You will want to use these to achieve it:

Selected Var(X) set Y 
Selected Var(X) mod [+/-]Y

Taking this opportunity to also ask if it is possible to modify a card variable depending on the number of specific cards and/or a type in a zone?

Yes, you would need to make use of Conditional Card Actions to check how many of a specific Cards or type there are in a Zone and then change those variables on a Selection of Cards.

Let us know in this thread or on the Discord if you need any help setting these up. We can troubleshoot it with you :)

(+1)
Sorry for the delay, it works!
And I have one more question, if you could answer: how do I make it so that when a card is discarded from the hand it goes back to the deck? Or be removed? Thank you again!

This is unfortunately a feature that is not available yet. But with the upcoming Card Game Combat v1.6.0 update, you should be able to make cards with these kinds of effects :)

Nice! Thank you ^^