It will probably work but it will work worse than windows build. I know for a fact that in multi monitor setup there would be bugs because unity screen and display properties give insane results on linux when there is more than 1 monitor. This wouldn’t happen with windows build. There is also issue with case sentitive file paths. While I fixed file names in scripts to match file name capitalization (and on current dev builds loading files is changed so capitalization in scripts no longer matters) but that can also cause issues. Also a lot of games from the period when valve pushed for linux support with native builds no longer work on most modern distros while wine can probably still run games from 90s.
OK, I guess I'm a little late with this topic. The problem with the size of the letters has always caused problems, especially in games whose add-ons were made by fans who didn't care about it at all. I use a laptop, so other than connecting it to a TV via hdmi, I've never had to set up multiple monitors. I use a rolling distribution, so I can very easily downgrade or upgrade the version of WINE I want to use. Anyway, thank you for your reply, I wish you fruitful work related to the game I really like.