Great game, I can't recommend it enough.
One suggestion for improvement though:
When setting up easier difficulties, it would be nice to have the choice of spending less modifier points than what's required to start a given run.
Sometimes you're 1 or 2 modifier points away from the required total, and the set of randomized rewards/penalties does not add up to something very usable, limiting actual selection options to maybe one or two rigid combinations in reality.
I'd rather have a run with, for example, 5/6 modifier points spent, than have a run where there's only one (less interesting) set I can actually go with, and the rest of the choices aren't actually possible combos.