Great concept that can easily turn into a fast paced roguelike with a constant stream of bombarding information.
Just some thoughts if it were to be developed further.
As the time goes, the effects can become more and more complex, like the ones with trade offs.
I think every once in a while, e.g. after a boss fight, the game can pause for a while for the player to reflect upon their own synergy and see how far they have gone.