Hi, yes, I just saw that... It starts too quickly, so the profile cannot be applied during the normal launch phase. It takes almost 1–2 secs to apply the all the parameters in the profile correctly. In YouTube VR case, all the parameters are set except the resolution (it takes more time to apply the resolution) but if the app/game is already loaded, the resolution can't be applied in-game. This must be applied furing the loading game phase or before the game start... Unfortunately, I can't really do something for that...
But what you can do is to disable the auto-detect feature in QGO general settings, then set the profile of your choice for the Home environment. So that when you launch YouTube, it will use the Home profile. Be sure to disable the YoutubeVR profile.