insight and dominos, that's all you need.
i got dominos early and on their own they are a great item. I ended up saving to unlock insight pretty quick expecting it to only last for one shot then you had to cast it again. Oh boy was i happily mistaken, insight stays active until you roll the barrel again, meaning you could end up with a full round of empty shots before you reach any bullets.
Pair insight with mana regen and the dominos and it became impossible to shoot myself unless i miss clicked, and i was never so low on mana that i couldn't cast it. (healing on the dominos was a bonus) I also got with the frog ring before long, which was a great addition to my set up. It added so much Hp, in exchange for evade and misfire stats, which had become obsolete due to insight, so no loss.
Frosting on the cake was an early 9 chamber pistol (got 10 just before the end) and the holy grail, which i didn't realize was a hat until i decided to shuffle my items around.
This build carried me from the fourth area blissfully to the final one. And the challenge became less "will i get shot" to "will i misclick and shoot myself".
Regardless, i played several rounds before this and loved it, the art, the absurdity, the leveling and mechanics, all super fun. Even the 'god run' i had was still very fun to play. (:
Good work to all you who worked on this!