Nice idea. I like the added challenge of having to explode the potions. I also really like the combo mechanism. I wonder what would happen to the gameplay if players could scroll through the colours with the scroll wheel on their mouse or with 2 buttons like Q/E instead of having to press 1-3. It might feel more intuitive and may have the benefit of keeping all the controls on the mouse. I found that trying to remember which was which number was a little hard with so much happening on screen. The music fits well.
Score was 942!