You should be able to find an altar which will accept a sacrifice of a given type of corpse. Find the right kind of corpse, bring it to the altar, and the shrine will crumble. Apologies that this wasn't made clearer - but thanks for playing! I really appreciate the feedback. A lot of things got left on the cutting room floor, one of which was a 'quests' dialog which would track these things for you - I'll try and make it a priority to bring that back in the first post-jam update, along with a bit more variety in how to unblock barriers.