I mean every word, and I shall keep my fingers crossed for your speedy recovery! They're dong amazing things with physical therapy these days :)
As to your question (I could only see one?), there is a possibility that side girls will turn on you if you haven't fully interacted with them in Act Two, but it will be rare - most often they'll just disappear when the war kicks off. In those cases there will be small amounts of lore you can find, indicating what happened to them.
I'm hoping that the new systems give players a lot to engage with, without feeling grindy or forced. CK is my first game, and so it's very much an experiment in seeing what works and what doesn't. I hope you enjoy the new stuff, though!
And seriously - get well soon! :)