Also I found that a surprisingly good drawing tool, including vector brushing, is OpenToonz.
https://github.com/opentoonz/opentoonz
I've actually made a whole jam game with such graphics once although it was rather on simplistic side.
(https://houkime.itch.io/withoutcowboy
You can measure the drawing time of all assets in making-of video https://peertube.social/videos/watch/8324b398-71ce-4108-99ba-e61a0029a9a3)
Because it is a dedicated animation tool you can do animated sprites right away.
And vector-drawn frame-by-frame animated sprites look quite cool and have unlimited resolution.
I have even submerged them into godot 3d space and they still look gorgeous even if i spent like 5 minutes on them.
It has some hiccups but I found it much easier and quicker to use than Krita on many occasions.