CHA will give you better seduction options in combat, which will help you have sex with them (as either top or bottom), but a lot of enemies won't be defeated by sex alone. Some will give up when dominated, some will be satisfied when they fuck you, but a lot of them will just keep on fighting until you're defeated. You can check the win/loss conditions with a little pop-out tab thing on the right/middle of the screen.
with decent charisma and the perk to heal when you eat cum, you can skate by early game by dropping to your knees. if you're careful you can get enough exp to buff up combat stats.
honestly you can dump strength if you go with agi and end; then you'll never half to worry about stamina and poise in combat, use backsteps and ripostes to trip up enemies and then kick/teabag them while they're down.