Every time I go for higher ATK SPD, e.g., spamming Lightning Wand, meteor, or anything — basically upgrading atk spd is just a bad idea.
Plus, the FPS drops significantly the further u get into the run. It got so ridiculous to the point the red chest is the only safe-haven where it comes back to 25+ from <10; the worse I've seen was 5 before it completely crashed.