If your Mac OS is version 11 or later, the game may not run through the Mac application. RPG Maker MV stopped supporting Mac after that version. (Or, from what I understand, it's more like Mac stopped supporting RPG Maker MV, but anyways.) The two solutions most likely to fix the issue are to move the game to your applications folder before running it, or to give the game read/write permissions. This link can help with that. https://support.apple.com/en-ca/guide/mac-help/mchlp1203/mac
I'm still not 100% sure if the game never works on newer operating systems, so you can give those solutions a try even if that is the case for you. Otherwise, you should be able to run the web version, though the players face and sprite won't reflect their appearance with that version due to plugin limitations.