Things I'm most interested in knowing:
1 - Who/What is behind the Alpha Werewolf, the Beta Werewolf and the sudden increase on werewolves attacks. During the Payback event, the MC ask himself if the Alpha is not natural from tha region, so who or what brought him there. This is something that could be inserted as a Caleb route thing, for both of you investigate it.
2 - Where is the teacher of the MC. He (as I remember) never visited Northcrest (as we know by now) and I don't think he went to Mythshore either (since there is a human city too). He's probably looking for the source of the Curse of the Lust but how he knows where it is? He received a message from someone warning him or he, from all the people, was the only one able to track the source of it?
3 - How exactly the Curse of the Lust works and spread? Maybe it's through the sex? That would explain why some people seems to be affected by it and some not. But Roushk and his soldiers loosed their minds to the curse after drinking water from the lake. The corrupted lake is the origin of the curse? How it got infected?
4 - The Wraith Fever is the first step of a bigger disease as we saw in Mythshore, it seems that, what happened there, was something more close to an experiment that gone wrong, as in Bareshade it seems that the origin of the disease was probably because of the rats coming from the Old Crypt near there. But why Bernard was the first one to get sick? The tunnel is connected to the bar, to the basement of the bar. Harold would have notice if he saw rats walking around but he just calls for you help a way before you solve the Wraith Fever thing. It just don't click for me.
Just some things that I think a lot.