The combination of body horror, mario and metroid is absolutely amazing, and the title screen was such a great gag.
Some feedback - It's REALLY easy to press R by accident. I'm guessing you don't want to add remappable controls or controller support, but maybe add a "long press" for R to respawn - could even have mario vibrate for a sec before he pops while you hold it as a little warning and it could look really hilarious.
The menu never moves from the top left, so this can occasionally make it extremely difficult to work your way up into the top left.
WASD is sort of supported for moving out parts in edit mode, but it seems especially in the early game to lose the cursor and this confused the heck out of me at first as I was just trying to use the keyboard or controller with keyboard keys mapped to it.
I was able to squeeze through this gap in the green area -
https://clips.twitch.tv/MistyStormyAubergineCorgiDerp-I0vdKdNfV7IiDZOi
I have no idea if this was cheese or intended, but if it's cheese I have NO IDEA where I was supposed to go. I feel like I've been able to proceed normally from here, though, but that power up down there, sticky, keeps respawning.
Overall experience was just amazing though. I'm having so much fun with it, and excited to finish it. I'm still kind of awestruck that somehow this combination of my favorite things - body horror, mario and metroid exists and was made by the creator of my favorite game ever and was just so goddamn fun.
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Thanks a lot for the feedback! Glad you enjoyed it!
For the controls suggestions, my initial plan was to have support for keyboard-only & gamepad input, but dropped those plans due to lack of time. My intention at the moment is to return to those features once I've rested a bit from the development, though. The WASD input you mentioned in Edit Mode is leftovers from this attempt to support non-mouse input, just left unfinished.
The route shown in the clip is indeed unintended, but in a way I'm glad it works because the game as it is lacks any guideposting so it's probably fairly easy not to know whether a given approach is correct or not. I might try to help with this a bit with later updates. The respawning powerup is definitely a bug, though; whoops.