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Depending on which expansions you use and how much space you have, 1--6 players is probably the most comfortable group size.

That said, if you have a huge crew of players, it's probably still pretty balanced. 9 players *can* defeat a 9 hits ghost in a single volley, but that many players trying to take pictures at once is going to be a little chaotic, and might cause some of them to miss. Likewise, 9 players will pretty much always take down a 1 hit ghost in a single round, but with the way the rules are written some of them may still miss and take damage in the process.

If you want to put the pressure on a 9 player group, have them fight three 1 hit ghosts back to back, rather than one 3 hit ghost.

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Essentially, the fewer players you have, the Fatal Frame-ier it is.

The more players you have, the Ghostbusters-ier it is.

I tend to prefer GMing for smaller group sizes, but if you trust all the players to keep track of their own HP totals and you have the scenario totally on rails, you could probably run it for a whole conference room.

In that case it'd probably feel like Time Crisis or Silent Scope.

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Fantastic, thank you for the comprehensive answer!