Did you redownload the base game? Downloading a DLC will open the DLC file that registers the DLC but isn't playable. To play the game, that has to be the most recent thing you downloaded.
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Then it's possible the updated files have gotten the attention of your virus scanner and it's blocking the game. Every time there's an update at least a few people end up having the game be falsely labeled as dangerous because each time new content is added there's a new chance for that to happen. Or it could be that the install had an error and trying again now that a little time has passed will have it install alright and be playable.