Good question!
At the moment there's a "genetic instability" system that does cause the player character to permanently change. It's not fully implemented yet, but your character's description in the mirror changes the more you bad end.
In terms of more immediate TF stuff in future content, it'll likely be planet-specific. There are plans for hyper, weight-gain, bimbofication, etc, which allow the player to keep playing, but they'll be specific to planets for those kinks. It's honestly just to save on complexity, since tracking body type, hyper endowment and the like for every single scene would occupy a lot of time and energy.