The profile error occurres when you have/had a different nw.js version on your system. It's not directly related to the game itself. There is a forum post about the issue and a possible solution here: https://forums.rpgmakerweb.com/index.php?threads/mv-profile-error-occurred-durin...
Depending on what anti-virus program you use, it should be possible to list the game as harmless before you start it, to prevent the anti virus from causing troubles.